Lange et al. Cell 2016

Lange et al. Genomics 2013

Lange et al. Nature 2011

Sasaki*, Lange* et al. NRMCB 2010

Lange et al. Cell 2009

Lange et al. NAR 2008 and website


See complete publication list by project below

Shattering the Genome

Lukaszewicz et al. Control of meiotic double-strand-break formation by ATM: local and global views. Cell Cycle 2018

Pacheco et al. ATR is required to complete meiotic recombination in mice. Nature Communications 2018

Widger et al. ATR is a multifunctional regulator of male mouse meiosis. Nature Communications 2018

Yamada et al. Genomic and chromatin features shaping meiotic double-strand break formation and repair in mice. Cell Cycle 2017

Jain et al. rahu is a mutant allele of Dnmt3c, encoding a DNA methyltransferase homolog required for meiosis and transposon repression in the mouse male germline. PLoS Genetics 2017

Stanzione et al. Meiotic DNA break formation requires the unsynapsed chromosome axis-binding protein IHO1 (CCDC36) in mice. Nature Cell Biology 2016

Lange et al. The landscape of mouse meiotic double-strand break formation, processing and repair. Cell 2016

Pacheco et al. The ATM signaling cascade promotes recombination-dependent pachytene arrest in mouse spermatocytes. PLoS Genetics 2015

Keeney et al. Self-organization of meiotic recombination initiation: general principles and molecular pathways. Annual Review of Genetics 2014

Roset et al. The Rad50 hook domain regulates DNA damage signaling and tumorigenesis. Genes & Development 2014

Biswas et al. Meiotic cohesin SMC1β provides prophase I centromeric cohesion and is required for multiple synapsis-associated functions. PLoS Genetics 2013

Kauppi et al. Numerical constraints and feedback control of double-strand breaks in mouse meiosis. Genes & Development 2013

Cole et al. Homeostatic control of recombination is implemented progressively in mouse meiosis. Nature Cell Biology 2012

Lange et al. ATM controls meiotic double-strand-break formation. Nature 2011

Daniel et al. Meiotic homologue alignment and its quality surveillance are controlled by mouse HORMAD1. Nature Cell Biology 2011

Sasaki*, Lange*, Keeney. Genome destabilization by homologous recombination in the germ line. Nature Reviews Molecular Cellular Biology 2010 (*co-first author)

The Y Chromosome


Lange* et al. Intrachromosomal homologous recombination between inverted amplicons on opposing Y-chromosome arms. Genomics 2013 (*co-corresponding author)

Lange et al. Isodicentric Y chromosomes and sex disorders as byproducts of homologous recombination that maintains palindromes. Cell 2009 [see news coverage in The New York Times]

Lange et al. MSY Breakpoint Mapper, a database of sequence-tagged sites useful in defining naturally occurring deletions in the human Y chromosome. Nucleic Acids Research 2008 [see user interface of database]

Repping et al. High mutation rates have driven extensive structural polymorphism among human Y chromosomes. Nature Genetics 2006

Repping et al. Recombination between palindromes P5 and P1 on the human Y chromosome causes massive deletions and spermatogenic failure. American Journal of Human Genetics 2002

Pediatric Cancer


Delattre et al. Un nouveau suppresseur de tumeur impliqué dans le modelage de la structure chromatinienne. Médecine Sciences 1998

Versteege et al. Truncating mutations of hSNF5/INI1 in aggressive paediatric cancers. Nature 1998